Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1549 | 1549-30811 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, L33LF, K43T | L10IV, K20KR, E35D, M36I, N37S, K55R, D60E, I62V, L63P, I64IV, I72V, Q92K |
| >1549-30811| codons 4-99 TLWQRPVVTIKIGGQLREALIDTGADDTVFEDISLPGRWTPKLIGGIGGFVRVRQYEQVP VEICGHKAVGTVLVGPTPANIIGRNLLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K43KE, S68G, K122E, I135T, Q174K, V179I, G196E, E203D, Q207D, R211K |
| >1549-30811| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPDIIIYQYMDDLYVGSDLEIEQHRTKIDELRDHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |