<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2052 2052-30630 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, I84V, L90M V11I, Q58E, G73C L10I, T12P, I13V, K14R, I15V, Q18H, K20I, M36I, N37S, R41K, D60E, I62V, L63P, I64IM, C67Y, A71T, I72L  
>2052-30630| codons 4-99
TLWQRPIIPVRVGGHLIEALLDTGADDTVLEEISLPGKWKPKIVGGIGGFVKVREYEQVP
MEIYGHKTLCTVLVGPTPVNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, M184I, L210W, T215Y D67G, K219R Y188L F227L T39K, K43E, E44D, V60I, K102KE, V118I, D123E, I135V, S162CY, I178FL, V179VI, T200A, E203K, Q207E, H208Y, R211K, K223E, L228H  
>2052-30630| codons 38-247
CKELEEDGKISKIGPENPYNTPIFAIKKKGSDKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKEKKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
AIFQYSMTKILEPFRKQNPDLIIYQYIDDLLVGSDLEIGQHRAKIKELREYLWKWGFYTP
DRKHQEEPPLHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006