Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2052 | 2052-30630 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | V11I, Q58E, G73C | L10I, T12P, I13V, K14R, I15V, Q18H, K20I, M36I, N37S, R41K, D60E, I62V, L63P, I64IM, C67Y, A71T, I72L |
| >2052-30630| codons 4-99 TLWQRPIIPVRVGGHLIEALLDTGADDTVLEEISLPGKWKPKIVGGIGGFVKVREYEQVP MEIYGHKTLCTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184I, L210W, T215Y | D67G, K219R | Y188L | F227L | T39K, K43E, E44D, V60I, K102KE, V118I, D123E, I135V, S162CY, I178FL, V179VI, T200A, E203K, Q207E, H208Y, R211K, K223E, L228H |
| >2052-30630| codons 38-247 CKELEEDGKISKIGPENPYNTPIFAIKKKGSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKEKKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDLIIYQYIDDLLVGSDLEIGQHRAKIKELREYLWKWGFYTP DRKHQEEPPLHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |