Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1856 | 1856-30506 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L33LF, F53L, G73S | L10I, R41K, D60E, L63P, H69R, A71V, I72L, V77I |
| >1856-30506| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGKWKPKIIGGIGGLVKVRQYEQIP IEICGRKVLSTVLIGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | Y188L | V179D | T39E, K49KR, T69TN, A98S, K103R, K173T, E203K, Q207A, H208Y, R211K, K223Q, V245T |
| >1856-30506| codons 38-247 CEEMEKEGKISRIGPENPYNTPVFAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKRKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRTQNPDIDIYQYMDDLLVGSDLEIGQHRTKIKELRAYLLKWGFFTP DQKHQQEPPFLWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |