Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1545 | 1545-30422 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82A, L90M | F53L, Q58E, G73S | L10I, I15V, G16A, K20R, E35D, M36I, R41K, I62V, L63P, A71V, I72L |
| >1545-30422| codons 4-99 TLWQRPIVTIKVAGQLREALLDTGADDTVLEDINLPGKWKPKIVGGIGGLVKVREYDQVP IEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, L210W, T215Y | K219R | K103N | T39A, K43E, E44D, T107TS, L109LI, V118I, K122P, I135T, T139I, S162Y, T200A, H208Y, R211K, D218E, K223Q, L228H, Q242H, V245E |
| >1545-30422| codons 38-247 CAELEEDGKISKIGPENPYNTPVFAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVSVIDVGDAYFSIPLDPDFRKYTAFTIPSTNNEIPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTP ERKHQQEPPFHWMGYELHPDKWTVHPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |