Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1543 | 1543-30411 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | L10F, G73S | I15V, R41K, I62V, L63P, I64IV, A71T, V77I, I93L |
| >1543-30411| codons 4-99 TLWQRPFVTIKVGGQLKEALLDTGADDTILEEMNLPGKWKPKIVGGIGGFMKVRQYDQVP VEICGHKTISTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V | V75I, K219Q | Y181YC, G190A | K49R, V60I, K122E, S162D, E169A, V179I, T200A, I202IV, Q207E, F214FL |
| >1543-30411| codons 38-247 CTEMEKEGKISRIGPENPYNTPIFAIKKKNSDRWRKLIDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILAPFRKQNPDIIICQYVDDLYVASDLEIGQHRAKVEELREHLLRWGLTTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |