Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2389 | 2389-30818 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | Y181C | A98G | E44D, V111VI, V118I, D123E, S163C, D177E, H208Y, R211K, W212LM, D218E |
| >2389-30818| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDIGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSCMTKILEPFRKQNPEIVICQYVDDLYVGSDLEIGQHRTKIEELRQYLWKMGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46L, I54V, V82A | L10F, L33F, N88D | I13V, K20T, I62V, L63P, A71V, V77I |
| >2389-30818| codons 4-99 TLWQRPFVTVKIGGQLTEALLDTGADNTVFEEMNLPGRWKPKLIGGIGGFVKVRQYDQVP IEICGHKVIGTVLIGPTPANIIGRDLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |