Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2070 | 2070-30609 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MIL, I50V | L10V, I15V, L19I, K43R, L63P, A71AV, Q92QK |
| >2070-30609| codons 4-99 TLWQRPVVTIKVGGQIKEALLDTGADDTVLEEMNLPGRWRPKLIGGVGGFIKVRQYDQIP IEICGHKVIGTVLVGPTPVNIIGRNLLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | G190A | V179E | K43E, E44A, K49R, V60I, S68G, K103R, K122E, I135T, S162C, V189A, I202M, E203D, H221Y, L228R, V245E |
| >2070-30609| codons 38-247 CTELEEAGKISRIGPENPYNTPIFAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIEIYQYMDDLYAASDLEIGQHRTKMDELRQHLWRWGFYTP DKKYQKEPPFRWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |