<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1987 1987-30602 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74LV, L210W, T215Y K219R Y181YC, Y188L   T39A, K43E, E44D, K102KM, V106VI, L109LI, V118I, K122E, D177E, Q207E, D218E, L228H  
>1987-30602| codons 38-247
CAELEEDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLKMKKSITVIDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPEIVICQYMDDLLVGSDLEIGQHRTKIEELREHLWRWGFYTP
ERKHQKEPPFHWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46IL, I54L, V82A, L90M L33F, K43T, G73S L10I, I13IV, K20KR, E35D, M36I, R41K, K55KR, I62V, L63P, A71V, I93L  
>1987-30602| codons 4-99
TLWQRPIVTVKIGGQLREALLDTGADDTVFEDINLPGKWTPKLIGGIGGFLRVRQYDQVP
IEICGHKVISTVLVGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006