Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1944 | 1944-30528 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W, T215Y | D67G, K219KR | Y181C | T39A, K43KE, E44ED, K49E, V118I, D123E, I135T, T139K, I142T, V179VI, E203K, Q207E, H208Y, R211K, K223E, L228HR |
| >1944-30528| codons 38-247 CAELEEDGKISEIGPENPYNTPVFAIKKKGSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSTNNEKPGTRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYMDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTP DRKHQEEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L10F, L33F, Q58E, L89V | I13V, I15IV, G16A, L19I, K20R, E35D, M36I, N37ND, R41RK, K55KR, R57K, D60E, I62V, L63P, A71T, I72V, Q92QK, I93F |
| >1944-30528| codons 4-99 TLWQRPFVTVKVAGQIREALLDTGADDTVFEDIDLPGKWKPKIIGGVGGFVRVKEYEQVP IEICGHKTVGTVLVGPTPANIIGRNVMTKFGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |