<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1944 1944-30528 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L210W, T215Y D67G, K219KR Y181C   T39A, K43KE, E44ED, K49E, V118I, D123E, I135T, T139K, I142T, V179VI, E203K, Q207E, H208Y, R211K, K223E, L228HR  
>1944-30528| codons 38-247
CAELEEDGKISEIGPENPYNTPVFAIKKKGSDKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSTNNEKPGTRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIIICQYMDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTP
DRKHQEEPPFRWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, V82A, L90M L10F, L33F, Q58E, L89V I13V, I15IV, G16A, L19I, K20R, E35D, M36I, N37ND, R41RK, K55KR, R57K, D60E, I62V, L63P, A71T, I72V, Q92QK, I93F  
>1944-30528| codons 4-99
TLWQRPFVTVKVAGQIREALLDTGADDTVFEDIDLPGKWKPKIIGGVGGFVRVKEYEQVP
IEICGHKTVGTVLVGPTPANIIGRNVMTKFGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006