Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1942 | 1942-30528 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | F53L, Q58E, G73S | L10I, I15V, N37D, K55R, I62V, L63P, A71V, I72L, I85V |
| >1942-30528| codons 4-99 TLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGLVRVREYDQVP IEICGHKVLSTVLVGPTPANIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75T, M184V, T215F | A62V, K219E | K103N | T39A, T69N, V118I, D123E, I135T, S162D, D177E, V179I, T200TA, F214L, L228H, V245M |
| >1942-30528| codons 38-247 CAELEKEGKISKIGPENPYNTPVFVIKKKNSNRWRKITDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPEIIIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGLFTP DEKHQKEPPFHWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |