Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1237 | 1237-30519 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L33F, K43T, F53L, T74P | L10IV, I13V, K14R, E21EQ, K55R, D60E, I62V, L63P, A71V, V77I |
| >1237-30519| codons 4-99 TLWQRPVVTVRIGGQLKQALLDTGADDTVFEEMNLPGRWTPKIIGGVGGLVRVRQYEQVP IEICGHKVIGPVLIGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67DN, T69TADN, L210LW | T215TCS | K43KN, V118I, K122E, I135M, R172RK, Q174QK, G196GE, T200TA, R211RT, V245VE |
| >1237-30519| codons 38-247 CTELENEGKISKIGPENPYNTPVFAIKKKNSNKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFKKKNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLWTWGFSTP DKKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |