Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1941 | 1941-30519 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54V, V82A, L90M | K43T | L10I, G16E, K20R, E35D, M36I, N37E, P39PS, I62V, L63H, A71I, V77I, I85V, I93L |
| >1941-30519| codons 4-99 TLWQRPIVTIKIEGQLREALLDTGADDTVLEDIELSGRWTPKMIVGVGGFVKVRQYDQVH IEICGHKIIGTVLIGPTPANIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, Q151M | T215I, K219E | L100I, K103N | T69N, S162N, I178L, V179I, G196E, Q207N, R211K, L228H | K122K* |
| >1941-30519| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLD*DFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQNSMTKILEPFRKQNPDLIIYQYMDDLYVGSDLEIEQHRTKIEELRNHLLKWGFITP DEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |