Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1240 | 1240-30519 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82F, L90M | L33F, Q58E | L10I, K20R, E34EA, E35D, M36I, N37D, D60E, Q61D, L63P, C67E, A71V, I85IV, I93L |
| >1240-30519| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVFADIDLPGRWKPKLIGGIGGFLKVREYEDIP IEIEGHKVIGTVLVGPTPFNIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | L100I, K103N | T39E, E44D, V118I, K122KE, I135IT, Q174QR, D177E, I178ILM, T200A, E203D, Q207K, R211D, E224ED |
| >1240-30519| codons 38-247 CEELEKDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPEMVIYQYVDDLYVGSDLEIGQHRAKIDELRKHLWDWGFYTP DKKHQKDPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |