Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 143P12 | 143P12W104 | U.S. | 1993 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 16 |
| 2 | DDI | 104 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R | S68G, T69I, R83K, Q207E, R211K, L228K |
| >143P12W104| codons 26-242 LTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKRKDGIKWRKLVDFRELNKKTQ DFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQ YNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEEL REHLLKWGFTTPDKKHQKEPPFKWMGYELHPDKWTVQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, E35D, N37X, L63P, I93L |
| >143P12W104| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMXLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Winters, MA | Human immunodeficiency virus type 1 reverse transcriptase genotype and drug susceptibility changes in infected individuals receiving dideoxyinosine monotherapy for 1 to 2 years. | AAC, 1997 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |