Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1128 | CA7509 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 47 |
| 2 | DDI+ AZT | 49 |
| 3 | DDC+ AZT | 5 |
| 4 | RTV+ DDI+ AZT | 22 |
| 5 | RTV+ AZT+ 3TC | 10 |
| 6 | IDV+ AZT+ 3TC | 15 |
| 7 | IDV+ D4T+ 3TC | 23 |
| 8 | SQV+ IDV+ D4T+ 3TC | 67 |
| 9 | ADV+ 3TC+ D4T+ NFV+ SQV | 44 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84IV | L24I | L10I, L63P, I64V, A71AV |
| >CA7509| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QIPVEICGHKVIGTVLVGPTPANVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219Q | E6D, T39A, E44D, K122E, I142IV, I202V, R211K, A288T |
| >CA7508| codons 1-302 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLWKWGFYTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKTLTEVIPLTEEAE LE |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |