Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1225 | 1225-30604 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210LW, T215Y | Y181YC | A98G | T69TN, K122PQ, E169D, D177E, H208HY, R211RK, L228LH | L109LQ, D110DE |
| >1225-30604| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVQEVGDAYFSVPLDQDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILDPFRKQNPEIVICQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54IV, V82VCFG, L90LM | L10I, R57K, L63P, I64L, A71AT, V77VI |
| >1225-30604| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVKQYDQIP LEICGHKTIGTVLIGPTPGNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |