Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1222 | 1222-30716 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184MV, L210LW, T215Y | K219KR | L100I, K103N | E44ED, V118I, K122E, V179I, T200A, E203D, Q207K, H208HY, R211K, L228R | K223KPQT |
| >1222-30716| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYVDDLYVGSDLEIGQHRAKIDELRKYLWKWGFYTP DRKHQTEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82VA, I84V, L90M | L10I, T12P, K20KR, E35D, M36IV, N37D, I62IV, L63P, A71T, I72V, V77I, I93L, C95CF |
| >1222-30716| codons 4-99 TLWQRPIVPIKIGGQLREALLDTGADDTVLEDVDLPGRWKPKIIGGIGGFVKVRQYDQVP IEICGHKTVGTVLIGPTPANVIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |