Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1540 | 1540-30708 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46IL, I54M, V82A, I84V, L90M | Q58QE | L10I, I15V, G16GA, K55R, R57K, D60DE, L63P, A71L, I93L |
| >1540-30708| codons 4-99 TLWQRPIVTIKVAGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFMRVKEYEQIP IEICGHKLIGTVLVGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | D67G, K219D | Y181C | E40F, K43Q, V60I, S68G, V118I, K122E, I142V, H208Y, R211K, L228H, V245T |
| >1540-30708| codons 38-247 CTFLEQEGKISKIGPENPYNTPIFAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTP DDKHQKEPPFHWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |