Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1539 | 1539-30625 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50IV, I54A, V82A, L90M | L33F | L10I, I13V, E34Q, N37H, R41K, I62V, L63S, A71V, V77I, Q92R, I93L, C95F | W6W* |
| >1539-30625| codons 4-99 TL*QRPIVTVKIGGQLKEALLDTGADDTVFQEMHLPGKWKPKIIGGVGGFAKVRQYDQVS IEICGHKVIGTVLIGPTPANIIGRNLMTRLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219N | K101P, K103N | K43N, V118I, K122E, D177E, T200A, E203D, Q207E, R211K |
| >1539-30625| codons 38-247 CTELENEGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLPKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIGQHRAKIDELREHLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |