Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1536 | 1536-30611 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L210LW, T215Y | K219KR | T39A, A98S, K122E, I135R, I195L, R211DEKN | D186DY |
| >1536-30611| codons 38-247 CAEMEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDYLYVGSDLELGQHRTKIEELRQHLWNWGFYTP DRKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54S, V82A | L33F, K43KT | L10I, I13V, R41K, K45KQ, I64V, T74S, V77I, I93L |
| >1536-30611| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTVFEEMNLPGKWTPQMIVGIGGFSKVRQYDQIL VEICGHKAIGSVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |