Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1535 | 1535-30610 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65R, Q151M, L210LW, T215DY | A62V, V75I, F77L | Y181C, Y188L | S68G, V106I, R172K, K173N, V189I, T200A, I202V, E203EK, H208HY, R211RK, K223T, L228HR, V245K | F116W |
| >1535-30610| codons 38-247 CTELEKEGKISKIGPENPYNTPVFVIKRKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYWSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFKNQNPDIVICQYMDDLLIGSDLEIGQHRAKVKELRQYLWKWGFYTP DKKHQTEPPFRWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | L10F, L33F, Q58E, G73S | L19I, K55KR, D60E, I62V, L63P, C67F, A71V, I72L, P79A |
| >1535-30610| codons 4-99 TLWQRPFVTIKIGGQIKEALLDTGADDTVFEEMNLPGRWKPKIVGGIGGFVRVREYEQVP IEIFGHKVLSTVLVGATPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |