Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1213 | 1213-30501 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, V82A, L90M | V11I, L33F, Q58E, G73GS | L10I, I13V, E35D, M36I, I62V, L63P, C67L, A71V, I72L | K20GMRV |
| >1213-30501| codons 4-99 TLWQRPIITVKIGGQLVEALLDTGADDTVFEDINLPGRWKPKMIGGIGGFLKVREYDQVP IEILGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | K103N, Y181C | K43KQ, V60VI, T69N, V90I, K122E, I135IT, G196E, T200A, E203D, R211RK, D218E, L228H, V245L |
| >1213-30501| codons 38-247 CTEMEQEGKISKIGPENPYNTPIFAIKKKNSNRWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIEQHRAKIDELRQHLLKWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPILLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |