Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1212 | 1212-30429 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I50V, I54V, V82S | L10I, G16GA, M36I, N37D, I62V, L63P, A71V, I72V |
| >1212-30429| codons 4-99 TLWQRPIVTIKIAGQLKEALLDTGADDTVLEEIDLPGRWKPKIIVGVGGFVKVRQYDQVP IEICGHKVVGTVLVGPTPSNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184V, T215Y | K219Q | K103N | T69N, K102R, K122E, D177E, I178M, E194K, G196E, Q207E | F77FV |
| >1212-30429| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSNKWRKLVDVRELNKRTQDFWEVQLGIPHP AGLKRNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEMVIYQYVDDLYVGSDLKIEQHRTKIEELREHLLRWGFYTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |