Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1210 | 1210-30508 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | V11I | L10I, T12A, I15V, L19T, K20I, E34Q, L63P, A71I, I93L |
| >1210-30508| codons 4-99 TLWQRPIIAIKVGGQTIEALLDTGADDTVLQEMNLPGRWKPKMIGGIGGFVKVRQYDQIP IEICGHKIIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115F, Q151M | A62V, K70KT, V75I, F77L, F116Y | K101KE, Y188L, G190A | S68G, V106VI, V118I, D121HY, K122E, S162C, R172K, D177E, T200A, V245T |
| >1210-30508| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKRKDGTTWRKLIDLRELNKRTQDFWEVQLGIPHP AGLEKKKSITVLDVGDAFYSIPLYEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQCSMTKILEPFKKQNPEIVIYQYMDDLLVASDLEIGQHRAKIEELRQHLLRWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |