Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1958 | 1958-30606 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K103N | V108I | K43E, T69TN, V118I, K122KE, Q174QK, G196E, T200TA, R206I, R211K, L228LI |
| >1958-30606| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKNSNKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPDIVIYQYVDDLYVGSDLEIEQHRAKIEELIQHLWKWGFYTP DKKHQKEPPFIWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L76V, V82F | L23I, L33I, Q58E | L10I, Q18E, K20KR, E34D, E35D, M36I, N37C, I62V, L63P, H69R, L89M |
| >1958-30606| codons 4-99 TLWQRPIVTIKIGGELREAILDTGADDTVIDDICLPGRWKPKMIGGIGGFVKVREYDQVP IEICGRKAIGTVVVGPTPFNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |