Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1957 | 1957-30908 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 14 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, L74V, L210LW, T215TNSY | K103N, Y181C | V108VI | V60VI, A98S, K122E, A158S, E203EK, R211RS | K223KPQT, Y232YH |
| >1957-30908| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP SIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKIKELRQHLWSWGFYTP DKKHQTEPPFLWMGHELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, L90M | M46V, Q58E, G73C | L10I, L19I, K20R, E35D, M36I, L63P, A71V, V77I, V82I, I93L |
| >1957-30908| codons 4-99 TLWQRPIVTIKIGGQIREALLDTGADDTILEDINLPGRWKPKVVGGIGGFMKVREYDQIP IEICGHKVICTVLIGPTPINIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |