Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1754 | 1754-30516 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | Y188L | K43E, E44D, V118I, S162C, T165TI, R172RK, L210S, R211K, D218E, L228H, V245I |
| >1754-30516| codons 38-247 CTELEEDGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMIKILEPFKKQNPDIVIYQYMDDLLVGSDLEIGQHRTKIEELRQHLSKWGFYTP EKKHQKEPPFHWMGYELHPDKWTVQPIILP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54M, V82A, L90M | L10I, L63P, A71I, I93IM |
| >1754-30516| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFMKVRQYDQIP IEICGHKIIGTVLVGPTPANIIGRNLMTQMGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |