Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1753 | 1753-30506 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | Y188L | K101H | K43KE, V60I, T200A, E203D, H208HY, R211K, V245K |
| >1753-30506| codons 38-247 CTELEEEGKISKIGPENPYNTPIFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLLVGSDLEIGQHRAKIDELRQYLLKWGFFTP DQKHQKEPPFLWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | V11I, G73T | L10I, T12P, I15V, L19P, K20I, E35ED, M36I, L63P, H69R, A71V, I72L, I85V |
| >1753-30506| codons 4-99 TLWQRPIIPIKVGGQPIEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVRQYDQIP IEICGRKVLTTVLVGPTPVNVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |