Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1752 | 1752-30505 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | V11I, F53L, L89V | L10I, T12S, I13V, L19Q, K20I, M36I, R41K, I62V, L63P, A71I, T74S, Q92R |
| >1752-30505| codons 4-99 TLWQRPIISVKIGGQQIEALLDTGADDTVLEEINLPGKWKPKLIGGIGGLVKVRQYDQVP IEICGHKIIGSVLVGPTPANIIGRNVMTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | L100I, K103N | T39TA, E44D, K102R, V118I, K122E, D123E, I135T, S162H, Q174R, V179VI, Q197K, R211AT |
| >1752-30505| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKRNKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQHSMTKILEPFRKRNPDIIIYQYMDDLYVGSDLEIGKHRTKIEELRQHLWTWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |