<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1751 1751-30502 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y K219R Y181C K101H, V108I T39A, K43Q, E44D, T107TS, V118I, K122E, D123DN, K166KR, V189I, G196E, E203K, Q207E, H208Y, R211K, K223T, L228H, Q242H  
>1751-30502| codons 38-247
CAELEQDGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLHKKKSVSILDVGDAYFSIPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTRILEPFRKQNPDIVICQYVDDLYIGSDLEIEQHRTKIKELREYLWKWGFYTP
DRKHQTEPPFHWMGYELHPDKWTVHPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, L33F, G73S I13V, K14R, E35D, M36I, N37D, I62V, L63P, A71V K20A
>1751-30502| codons 4-99
TLWQRPFVTVRIGGQLAEALLDTGADDTVFEDIDLPGRWKPKIIGGIGGFVKVRQYDQVP
IEICGHKVISTVLVGPTPVNVIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006