Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1751 | 1751-30502 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33F, G73S | I13V, K14R, K20A, E35D, M36I, N37D, I62V, L63P, A71V |
| >1751-30502| codons 4-99 TLWQRPFVTVRIGGQLAEALLDTGADDTVFEDIDLPGRWKPKIIGGIGGFVKVRQYDQVP IEICGHKVISTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K219R | Y181C | K101H, V108I | T39A, K43Q, E44D, T107TS, V118I, K122E, D123DN, K166KR, V189I, G196E, E203K, Q207E, H208Y, R211K, K223T, L228H, Q242H |
| >1751-30502| codons 38-247 CAELEQDGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVSILDVGDAYFSIPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIVICQYVDDLYIGSDLEIEQHRTKIKELREYLWKWGFYTP DRKHQTEPPFHWMGYELHPDKWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |