Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1750 | 1750-30418 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | K219R | V108I, K238N | K43Q, E44D, K64R, V118I, T200TA, H208HY, R211K, L228R, V245Q | R206I |
| >1750-30418| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIRKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTILDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELIQYLWKWGFYTP DRKHQKEPPFRWMGYELHPDNWTVQPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, V82A | L24I, Q58E, G73A, T74P, L89V | L10IV, L33M, N37D, K55R, I62V, L63P |
| >1750-30418| codons 4-99 TLWQRPVVTIKIGGQLKEALIDTGADDTVMEEMDLPGRWKPKLIVGIGGFIRVREYDQVP IEICGHKAIAPVLVGPTPANIIGRNVLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |