Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1201 | 1201-30307 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54V, V82A, L90M | L10F, L33F, Q58E, N88D | I13V, K20R, E35D, M36I, N37S, R41K, L63P, A71T |
| >1201-30307| codons 4-99 TLWQRPFVTVKIGGQLREALLDTGADNTVFEDISLPGKWKPKMIGGIGGFVKVREYDQIP IEICGHKTIGTVLVGPTPANIIGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, V75AT, M184V, L210W, T215Y | A62V | K103N | K43E, V118I, D123E, I142V, T200A, R211K, L228LH, V245Q |
| >1201-30307| codons 38-247 CTELEEEGKISKIGPENPYNTPVFVIKKKNSTKWRKLTDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |