Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1200 | 1200-30228 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A, I84V, L90M | L33F, Q58E | L10I, I13V, K20R, E35D, M36I, L63P, A71V, I72V, I93L |
| >1200-30228| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTVFEDINLPGRWKPKLIGGIGGFLKVREYDQIP IEICGHKVVGTVLVGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K219N | Y181C | V108I | E40F, K43E, V60I, V118I, K122E, I142V, K166R, Q174R, H208Y, R211K, H221Y, V245R |
| >1200-30228| codons 38-247 CTFLEEEGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKRNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTP DNKYQKEPPFLWMGYELHPDKWTVQPIRLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |