Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2123 | 2123-30725 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90LM | F53L | L10V, K20R, E35D, M36V, N37E, R41RK, D60E, L63P, A71V, V77I, I93L |
| >2123-30725| codons 4-99 TLWQRPVVTIKIGGQLREALLDTGADDTVLEDVELPGKWKPKMIGGIGGLVKVRQYEQIP IEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | K101E, Y188YFHL, G190GA | V60VI, A98AS, V118VI, K122E, S162SDGN, K166R, D177E, Q197QK, I202V, E204EK, H208Y, R211RK, L228LH |
| >2123-30725| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP SGLEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTRILEPFRKQNPEIVIYQYVDDLLVASDLEIGKHRTKVEKLRQYLLKWGFFTP DQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |