Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1690 | 1690-30501 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | L10F, L33F, G73A | I13V, E34Q, L63P, I66F, H69Q, V77I |
| >1690-30501| codons 4-99 TLWQRPFVTVKIGGQLKEALLDTGADDTIFQEMNLPGRWKPKIVGGIGGFMKVRQYDQIP IEFCGQKAIATVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, L210W | A62V, T215H | G190S | K101H | A98S, K122E, D123DN, I135T, I178IM, T200A, H208Y, R211K, L228R, V245E |
| >1690-30501| codons 38-247 CTELEKEGKISKIGPENPYNTPVFVIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHP SGLHKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMVIYQYMDDLYVSSDLEIGQHRAKIEELRQYLWKWGFHTP DKKHQKEPPFRWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |