Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1689 | 1689-30428 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, Y115F, M184MV | Y181C | K49R, K122E, I135T, A158S, T165TI, E169D, I178L, R211K, L228Q, D237E, V245M |
| >1689-30428| codons 38-247 CTEMEKEGKISRIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAFFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP SIFQSSMIKILDPFRKQNPDLVICQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTP DKKHQKEPPFQWMGYELHPEKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54V, V82A, L90M | L10F, V11VI, L33F, G73S, L89V | T12TS, I13V, K14KR, I15V, L19V, K20R, M36I, I62V, L63P, H69Q, A71V, I93M |
| >1689-30428| codons 4-99 TLWQRPFISVRVGGQVREALLDTGADDTIFEEINLPGRWKPKMVGGIGGFVKVRQYDQVP IEICGQKVISTVLVGPTPANIIGRNVMTQMGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |