Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1688 | 1688-30417 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, L210W, T215Y | K219E | K103N, Y181YC, G190GA | V108VI | T39A, V60I, R83K, A98S, K122E, I135L, T139TM, S162A, R211K, H221HY, L228H |
| >1688-30417| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLMDFRELNKKTQDFWEVQLGIPHP SGLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSLNNEMPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTP DEKYQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82VA, L90M | G73S | L10V, I15V, K20M, E35G, M36I, N37ND, I62V, L63P, C67F, I72L |
| >1688-30417| codons 4-99 TLWQRPVVTIKVGGQLMEALLDTGADDTVLEGIDLPGRWKPKIIGGIGGFVKVRQYDQVP IEIFGHKALSTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |