Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1190 | 1190-30310 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, V75M, M184V, L210W, T215Y | L100I, K103N | T39A, K43E, T69N, K102R, V118I, K122E, D177G, G196E, T200TA, E203K, Q207E, K223T, L228R, I244IV |
| >1190-30310| codons 38-247 CAELEEEGKISKIGPENPYNTPVFAIKKKDSNKWRKVMDFRELNKRTQDFWEVQLGIPHP AGIKRNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPGIVIYQYVDDLYVGSDLEIEQHRAKIKELREHLWRWGFYTP DKKHQTEPPFRWMGYELHPDKWTVQPVVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, I84V, L90M | L10F, L33F | I13V, L19IT, K20R, E34A, E35D, M36I, K43Q, I62IV, L63P, A71I, P79S, L89I |
| >1190-30310| codons 4-99 TLWQRPFVTVKIGGQTREALLDTGADDTIFADINLPGRWQPKMVGGIGGFMKVRQYDQVP IEICGHKIIGTVLVGSTPVNVIGRNIMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |