Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1637 | 1637-30506 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, M184V | Y181C | V60I, S68G, V90I, V118I, I135T, S162D, Q207E, R211K, F214L, P243H, V245E |
| >1637-30506| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKDGTKWRKVVDFRELNKRTQDFWEIQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQHIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84IV | L10F, L24I, L33F | T12P, I13V, K14R, K20T, N37H, R41K, L63P, K70KE, A71V, V77VI, I93L |
| >1637-30506| codons 4-99 TLWQRPFVPVRIGGQLTEALIDTGADDTVFEEMHLPGKWKPKIIGGIGGFVKVRQYDQIP IEICGHEVIGTVLIGPTPANVIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |