Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1196 | 1196-30912 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 27 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, I84V, L90M | V11I, G73T | L10I, I13V, Q18H, K20I, L33V, M36I, F53W, K55KR, L63P, I64V, A71V, I72IT |
| >1196-30912| codons 1-99 PQITLWQRPIITVKIGGHLIEALLDTGADDTVVEEINLPGRWKPKIIGGIGGWARVRQYD QIPVEICGHKVTTTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, D67N, T69D, K70R, Q151M | V75I, F116Y, K219Q | G190A | Y318F | A33V, V60I, V118I, K122E, D123E, I142V, S162Y, Q174K, N175Y, I178M, I180V, G196E, F214L, L228H, V245E, I293V, E297K, K331KR, Q334L, F346Y, M357T, G359S, V365I, T386I, I393IM | K102Y |
| >1196-30912| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKVLVEICTEMEKEGKISKIGPENPYNTPI FAIKRKNSDRWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKYKKSVTVLDVGDAYYSIPL DEEFRKYTAFTIPSINNETPGVRYQYNVLPMGWKGSPAIFQYSMTKILEPFRKKYPDMVV YQYMDDLYVASDLEIEQHRTKIEELRQHLLRWGLTTPDQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVFYDPSKDLIAEIQRQGLGQWTYQIYQEPYKNLKTGKYARTRSA HTNDIKQLTEAVQKIATESIVIWGKIPKFKLPMQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |