Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1196 | 1196-30306 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54MV, I84V, L90M | L10F, V11I, G73T | I13V, Q18H, K20I, M36I, F53W, L63P, I64V, A71V, I72T |
| >1196-30306| codons 4-99 TLWQRPFITVKIGGHLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGWVKVRQYDQIP VEICGHKVTTTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Q151M | V75I, F116Y, K219Q | K103N | V60I, K102*, V118I, K122E, D123E, I135T, S162Y, Q174K, N175Y, D177E, I178IM, I180V, G196E, F214L, L228H, V245E |
| >1196-30306| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKLIDFRELNKRTQDFWEVQLGIPHP AGLK*NKSVTVLDVGDAYYSIPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQYSMTKILEPFRKKYPEMVVYQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGLTTP DQKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |