Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1193 | 1193-30305 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, M184V | T215I, K219Q | K103S, G190A | T39A, S48E, V60I, V118I, I135T, K166R, V179VI, E194K, G196E, F214L, L228H |
| >1193-30305| codons 38-247 CAEMEKEGKIEKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKSKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIIIYQYVDDLYVASDLKIEQHRTKIEELRQHLLRWGLITP DQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, V82A | L33F, I47IK, N83D | L10I, I13V, K20R, M36L, R41N, K45I, D60E, I62V, L63P, I64V |
| >1193-30305| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTVFEELNLPGNWKPIMKGGIGGFAKVRQYEQVP VEICGHKAIGTVLVGPTPADIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |