Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1632 | 1632-30304 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10I, K20R, E35D, M36I, N37S, R41K, I62V, L63P, K70R, A71I, I72L, V77T |
| >1632-30304| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVLEDISLPGKWKPKMIGGIGGFIKVRQYDQVP IEICGHRILGTVLTGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65KR | A62AV | Y181YC | K43E, K49KR, S68SG, D123E, I135T, I202V, Q207AE, R211K, F214L, L228H |
| >1632-30304| codons 38-247 CTEMEEEGKISRIGPENPYNTPVFVIKRKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKVEELREHLLKWGLTTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |