Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1198 | 1198-30304 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, L76LV, V82VA, L90LM | L33F, Q58E, G73GAST | L10I, I13V, L19LI, E34EQ, N37D, K55KR, I62IV, L63LP, A71T, I72IL, V77I |
| >1198-30304| codons 4-99 TLWQRPIVTVKIGGQIKEALLDTGADDTVFQEMDLPGRWKPKIIGGIGGFLRVREYDQVP IEICGHKTLTTVVIGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184V | T215I, K219E | L100I, K103N | K102R, V118I, K173S, D177DE, I178L, V179I, T200A, I202V, F214L, L228H, V245E |
| >1198-30304| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGIKRNKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRSQNPELIIYQYVDDLYVGSDLEIGQHRAKVEELRQHLLRWGLITP DEKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |