Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1194 | 1194-30303 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, K43T | L10V, T12TK, I15V, L19LP, K20M, E35ED, M36V, R41RK, K55KR, Q61QH, I62V, L63P, I64V, I72IV, T74S, I85V, T91S |
| >1194-30303| codons 4-99 TLWQRPVVKIKVGGQPMEALIDTGADDTVLEDVNLPGKWTPKLIGGIGGFVRVRQYDHVP VEICGHKAVGSVLVGPTPANIVGRNLLSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R | K103N, Y188HL | S68G, K102Q, K122E, I135T, S162Y, D177E, T200A |
| >1194-30303| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKRKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKQNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPEIVIYQYMDDLLVGSDLEIGQHRAKIEELRQHLLRWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |