Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1189 | 1189-30228 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115F, Q151M, M184V | A62V, V75I, F77L, F116Y, T215C | Y188L, G190A | K49Q, S68G, K70X, K101Q, S162C, S163SAGT, I167IV, T200A, D237E |
| >1189-30228| codons 38-247 CTEMEKEGKISQIGPENPYNTPVFVIKKKDGTXWRKLIDLRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAFYSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQCTMTKVLEPFRKQNPDIVIYQYVDDLLVASDLEIGQHRAKIEELRQHLLRWGFCTP DKKHQKEPPFLWMGYELHPEKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | V11I, K43T, G73S, L89V | L10I, I15V, Q18H, L19T, K20I, E34D, M36I, L63P, H69K, A71V, I85V |
| >1189-30228| codons 4-99 TLWQRPIITIKVGGHTIEALLDTGADDTILDEINLPGRWTPKIVGGIGGFMKVRQYDQIP IEICGKKVISTVLVGPTPANIVGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |