Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1179 | 1179-30609 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A | L24I, K43T | L10I, T12P, I15V, L19I, E35ED, M36MI, R41K, K55R, D60E, I62V, L63P, A71V, I72IT, I93L |
| >1179-30609| codons 4-99 TLWQRPIVPIKVGGQIKEALIDTGADDTVLEDINLPGKWTPKIIGGIGGFVRVRQYEQVP IEICGHKVTGTVVVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69DEKN, K70EG, V75T, Y115F, Q151M, M184V | A62V, D67DG | K101E, Y181C, G190A | E138K | K43E, K49R, S68SG, K82KR, D123E, I135T, D177E, Q207N, R211K, F214L, L228LH, V245E |
| >1179-30609| codons 38-247 CTEMEEEGKISRIGPENPYNTPVFVIKKKGGNGWRKLTDFRELNRRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAFFSVPLDKEFRKYTAFTIPSTNNKTPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPEIVICQYVDDLYVASDLEIGQHRTKIEELRNHLLKWGLTTP DKKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |