Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1175 | 1175-30519 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, L90M | V11I, F53L | L10I, I15V, L63P, A71V |
| >1175-30519| codons 4-99 TLWQRPIITIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGVGGLIKVRQYDQIP IEICGHKVIGTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | V75L | K103N, V106A | K43E, A98AS, I135V, D177E, I178L, H208Y, R211K, V245K |
| >1175-30519| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKNSTKWRKVLDFRELNKRTQDFWEVQLGIPHP SGLKKNKSATVLDVGDAYFSVPLDKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPELVIYQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |