Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1159 | CA7495 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 9 |
| 2 | DDI | 26 |
| 3 | D4T | 18 |
| 4 | AZT+D4T+IDV | 26 |
| 5 | AZT+DDI+NVP+RTV+SQV | 9 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V106A | V35L, E79ED, V179I, G196E, T200A, E203EK, Q207E, E248D | L168LI, Q258QH, V261VL, L264LF, N265NS |
| >CA7495| codons 1-270 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRDLNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKIIEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRAKIKELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIHKLLGKFSWASQI |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A, I84V | D60E, L63P, K70T, L89M |
| >CA7496| codons 18-99 QLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYEQIPIEICGHTAIGTVLV GPTPANVIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |